cancer doctors

Breast Cancer Types

Question: Which Breast Cancer types arent receptive to Oestrogen and Hormones? As in histological types, please could you cite your references :)

Answer: Answer: ER-Negative and PR-Negative Breast Cancers. Immunohistochemistry lab testing procedures of breast cancer tumors for certain features (such as estrogen receptor assays, progesterone receptors assays, and HER-2/neu) is a major step in deciding which type of breast cancer are receptive or not receptive to estrogen and progesterone (hormones) within our body. For doctors knowing this this allows them more leverage in decision making as to what is best for your particular cancer situation. Aside from HER-2/neu which is a type of receptor protein that helps cells to grow in cancer in a more agressive fashion, the two hormones in women of most concern is estrogen and progesterone. These two hormones stimulate the growth of normal breast cells and play a major role in many breast cancer treatment options. Cancer cells tend to respond to these hormones through the estrogen receptors (ER) and progesterone receptors (PR). ER and PR are a cells welcoming mat for these hormones circulating throughout the bloodstream. Cancer tumors are tested for these receptors in a test called a hormone receptor assay. If a cancer does not have these receptors, it is referred to as hormone receptor negative (estrogen-receptor negative and progesterone-receptor negative). If the cancer has these receptors, it is referred to as hormone receptor positive (ER-receptor positive and/or PR-receptor positive) or just ER-positive or PR-positive. Positive or negative receptor hormones within breast lesions is what matters here. The hormone receptors are important because cancer cells that are ER or PR-positive often stop growing if the woman takes drugs that either block the effect of estrogen and progesterone or decrease the body's levels of estrogen. these drugs lower the chance that the cancer will come back or recur and also improve the chances of the patient living longer. Most women with ER-positive or PR-positive cancer will take these drugs as part of their chemotherapy treatment protocol. However, these hormones-active drugs are not effective if your cancer does not contain these receptors.


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