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Colorectal Cancer Therapy

Question: How effective is Avastin as targetted therapy for the metastatic colorectal cancer? What could be the possible side-effects? I would appreciate personal experiences very much! Thanks! The loved one is none other than my precious mom. She has already had 2 doses of Avastin within a gap of 15 days...on 21st Apr. & 5th May. No serious side-effects so far. But the doctor says to wait till the third dose on 20th May. If she withstands that, things would hopefully perk up.

Answer: Taking Avastin, an FDA-approved monoclonal antibody and anti-angiogenesis drug (almost always in combination with intravenous 5-FU), for metastatic colorectal cancer is NOT exactly like the old Doc's advice: "Take two Aspirins and call me in the morning!" This is a serious medical issue/decision that must be thoroughly discussed with the patient's attending physician/oncologist and other members of the interdisciplinary treatment team. As with any chemotherapy regime the side effects could vary from patient to patient; BUT they are potentially VERY SERIOUS (e.g. gastrointestinal perforation, hemoptysis, severe wound healing complications, etc.) ... One of my most precious friends is currently on it, and I can tell you, it has NOT exactly been a walk in the park for him! :-( :-( You may find the following web sites quite informative (if you haven't seen them already, that is): http://www.avastin.com/avastin/index.jsp?hl=en&q=Avastin http://www.gene.com/gene/products/information/oncology/avastin/ http://www.drugs.com/avastin.html Be well always, and all the best to your "loved one". .


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