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Endometrial Cancer Treatment

Question: Is tamoxifen a must for ER/PR negative menstruating lady for breast cancer treatment? i m 32 years old treated for breast cancer 1 year before and was advised tamoxifen. since i had endometrial hyperplasia, tamoxifen was stopped and started letrozol. now i m advised to stop that also and go back to tamoxifen, ER/PR negative. what can be done?

Answer: Tamoxifen (also known as Nolvadex) is a synthetic compound similar to estrogen. It mimics the action of estrogen on the bones and uterus, but blocks the effects of estrogen on breast tissue. Tamoxifen is used as adjuvant hormonal therapy immediately after surgery in early stages of breast cancer and in advanced metastatic breast cancer (stages III and above) in women. Tamoxifen belongs to a family of compounds called antiestrogens. Antiestrogens are used in cancer therapy to inhibit the effects of estrogen on target tissues. Estrogen is a steroid hormone secreted by the female ovary. Depending on the target tissue, estrogen can stimulate the growth of female reproductive organs and breast tissue, play a role in the female menstrual cycle, and protect against bone loss by binding to estrogen receptors on the outside of cells within the target tissue. Antiestrogens act selectively against the effects of estrogen on target cells in a variety of ways, thus they are called selective estrogen receptor modulators (SERMs). Depending on various health factors and improvement of the patient antiestrogens are stopped and started again. I feel your Oncologist might have felt the necessity to stop and then again resume Tamoxifen in your case. It is in order to give negative menstruating breast cancer patients. Hence you may take it as advised by your doctor. Best of luck. - Addition - The reason for Tamoxifen may be because ER/PR+/HER2- cancers are often not extremely responsive to chemotherapy. However, they generally do respond to Tamoxifen.-

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